Exploitation of sulfated glycosaminoglycan status for precision medicine of platinums in triple-negative breast cancer
J. D. Hampton, E. J. Peterson, S. J. Katner, T. H. Turner, M. A. Alzubi, J. C. Harrell, M. G. Dozmorov, P. J. Gigliotti, V. Kraskauskiene, M. Shende, M. O. Idowu, M. Puchalapalli, B. Hu, L. Litovchick, E. Katsuta, , J. E. Koblinski
This study identifies sulfated glycosaminoglycan (sGAG) levels as a biomarker predicting response to Triplatin in triple-negative breast cancer (TNBC), showing improved efficacy compared to carboplatin in sGAG-high tumors.
bioRxiv · May 5, 2021Pharmacology & Toxicology