B. Hu

ChIPbinner: An R package for analyzing broad histone marks binned in uniform windows from ChIP-Seq or CUT&RUN/TAG data

ChIPbinner provides an R package for analyzing broad histone marks by binning the genome into uniform windows, enabling unbiased comparison between samples and identification of differential bins.

Nuclear stiffening in neoplastic cells aggregates T cell exhaustion via pFAK/SP1/IL-6 axis in colorectal cancer

The paper shows that nuclear stiffening in colorectal cancer cells promotes T cell exhaustion through the pFAK/SP1/IL-6 axis, and inhibiting pFAK improves antitumor immunity.

Epidermal Growth Factor Receptor Regulates Beclin-1 in Hyperoxic Acute Lung Injury

This study shows that EGFR regulates Beclin-1 and autophagy in hyperoxic acute lung injury, suggesting a novel therapeutic pathway.

Targeting of SUMOylation leads to cBAF complex stabilization and disruption of the SS18::SSX transcriptome in Synovial Sarcoma

This study shows that inhibiting SUMOylation with TAK-981 stabilizes cBAF complexes and disrupts the SS18::SSX-driven transcriptome in synovial sarcoma, leading to tumor inhibition.

African Swine Fever Virus Protein B263R Inhibits Autophagy by Promoting Proteasomal Degradation of Beclin1

This study identifies B263R as an ASFV protein that inhibits autophagy by promoting proteasomal degradation of Beclin1, highlighting its role in viral replication and potential therapeutic targets.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Damage sensing through TLR9 Regulates Inflammatory and Antiviral Responses During Influenza Infection

This study shows that TLR9 sensing of tissue damage during influenza infection promotes inflammation and antiviral responses, but its absence leads to impaired viral clearance and prolonged lung injury.

Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis

This study shows proteasome inhibitors are more effective against NSCLC cells with mutant p53 by inducing oxidative stress and mitochondrial apoptosis, suggesting a new therapeutic strategy.

Characterization of the SARS-CoV-2 BA.5 Variants in H11-K18-hACE2 Hamsters

This study characterizes SARS-CoV-2 BA.5 variants in H11-K18 hACE2 golden hamsters, showing disease progression and severity similar to human infections, supporting the model's utility for research.

In vivo affinity maturation of the HIV-1 Env-binding domain of CD4

This study demonstrates that non-antibody protein biologics can undergo affinity maturation in vivo, leading to improved binding affinity and neutralization potency against HIV-1.

The role of m6A methyltransferase WTAP in inflammatory response of atherosclerosis through NF-κB/NLRP3 mediated pyroptosis

This study shows that WTAP promotes LPS-induced pyroptosis and inflammation in endothelial cells by enhancing NF-κB p50 function and facilitating its interaction with NLRP3.

Recommendations For a Standardized Approach to Histopathologic Evaluation of Synovial Membrane in Murine Models of Experimental Osteoarthritis

The paper develops a standardized histopathologic evaluation approach for synovial membrane in murine OA models, showing good inter-reader agreement and consistent findings across stains.

Diversity and ecological functions of viruses inhabiting the oil reservoirs

This study identifies a diverse range of viruses in oil reservoirs and their ecological roles in regulating microbial communities and biogeochemical cycles.

CCL19, not CCL21 induces CCR7-mediated stimulation of leukemia apoptosis by targeting endosomal signaling signaling

The paper was withdrawn due to lack of author consent and is not intended for citation.

A mutation-mediated host shift drives Avian paramyxovirus type 1 evolution

This study identifies mutations in the P protein of Avian paramyxovirus type 1 that drive host shift from chickens to pigeons through enhanced degradation of LSm14A.

Intestinal microbiota modulates the anti-tumor effect of oncolytic virus vaccine in colorectal cancer

This study shows that intestinal microbiota enhances the anti-tumor effect of oncolytic virus vaccine in advanced colorectal cancer by modulating T-cell activity.

Alterations in the preneoplastic breast microenvironment of BRCA1/2 mutation carriers revealed by spatial transcriptomics

This study uses spatial transcriptomics to identify microenvironmental and signaling differences in preneoplastic breast tissues of BRCA1/2 mutation carriers compared to non-carriers.

Development of a human glioblastoma model using humanized DRAG mice for immunotherapy

This study develops a humanized DRAG mouse model to test GBM immunotherapy, showing anti-PD-1 antibodies reduce immunosuppressive cells in xenografted tumors.

SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4

This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.

Inhibition of LATS Kinases in Ovarian Cancer Activates Cyclin D1/CDK4 and Decreases DYRK1A Activity

This study shows that inhibiting LATS kinases in ovarian cancer cells activates cyclin D1/CDK4 and reduces DYRK1A activity, promoting tumor growth.

Conformational dynamics of cohesin/Scc2 loading complex are regulated by Smc3 acetylation and ATP binding

This study identifies how Smc3 acetylation and ATP binding regulate the dynamic conformations of the cohesin/Scc2 complex during chromosome loading.

Repurposing clemastine to target glioblastoma cell stemness

This study shows clemastine, an antihistamine, reduces glioblastoma stemness by targeting EBP, a cholesterol pathway enzyme, and promotes differentiation of oligodendrocyte progenitor cells.

PF-D-Trimer, a broadly protective SARS-CoV-2 subunit vaccine: immunogenicity and application

This paper presents a subunit vaccine, PF-D-Trimer, derived from the Delta spike protein, showing robust immunogenicity and cross-reactive neutralizing antibodies against multiple SARS-CoV-2 variants.

Limitations of Busulfan to Create Humanize Mice with an Innate Immune System.

This study evaluates busulfan's effectiveness in preconditioning humanized mice for immune cell engraftment, finding it works well for hIL15-Tg-NSG but not SGM3-NSG mice.

Development and application of an uncapped mRNA platform

The paper develops an uncapped mRNA platform and demonstrates its effectiveness in inducing immune responses and protein expression in vitro and in vivo.

Genomic screening reveals UBA1 as a potent and druggable target in c-MYC-high TNBC models

The paper identifies UBA1 as a druggable target in c-MYC-high TNBC models, showing TAK-243 induces ER-stress and apoptosis in vitro and in vivo.

Key mutations on spike protein altering ACE2 receptor utilization and potentially expanding host range of emerging SARS-CoV-2 variants

This study identifies key spike protein mutations in SARS-CoV-2 variants that enhance ACE2 receptor utilization across multiple animal species, potentially increasing host range and spillover risk.

Bipartite recruitment of PCH2 and COMET to the synaptonemal complex drives chromosome axis reconstruction leading to crossover restriction

This study shows that PCH2 and COMET are recruited to the synaptonemal complex via ZYP1 to regulate ASY1 removal and crossover restriction during meiosis.

The Arabidopsis Hop1 homolog ASY1 mediates cross-over assurance and interference

This study investigates the role of ASY1 in meiotic crossover (CO) assurance and interference in Arabidopsis, showing that reduced ASY1 activity leads to altered CO distribution and genomic instability.

Slit-Robo Signalling Establishes a Sphingosine-1-Phosphate Gradient to Polarise Fin Mesenchyme and Establish Fin Morphology

The paper shows that Slit-Robo signaling coordinates with S1P to polarize fin mesenchyme and establish fin morphology in zebrafish.