Cancer BiologybioRxiv
Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations
A. Subramaniam, C. Sanden, L. Moura-Castro…·J. Larsson
This study demonstrates that partial STAG1 perturbation selectively kills STAG2-mutated AML cells while sparing normal HSCs, showing synthetic lethality in xenograft models.
DOI 10.3324/haematol.2021.280303