J. Larsson

Pooled optical screening in bacteria using chromosomally expressed barcodes

The paper develops a method for in situ genotyping of bacterial libraries using chromosomally expressed barcodes to measure intracellular maturation times of red fluorescent proteins.

Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails

The paper predicts rapid temporal adaptation in marine snails using spatial genetic and phenotypic variation from a 30-year transplant experiment, finding observed changes align with predictions.

Antibiotic perseverance increases the risk of resistance development

The paper uses single-cell imaging to study antibiotic resistance in E. coli and finds that growth perseverance increases resistance development.

Structural Characterisation of Nanoparticle-Supported Lipid Bilayers by Grazing Incidence X-ray and Neutron Scattering

This study uses grazing incidence X-ray and neutron scattering to analyze the structure of curved and fluid lipid bilayers formed on nanoparticle arrays, revealing curvature effects on lipid packing.

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations

This study demonstrates that partial STAG1 perturbation selectively kills STAG2-mutated AML cells while sparing normal HSCs, showing synthetic lethality in xenograft models.

Rapid antibiotic susceptibility testing and species identification for mixed infections

This paper presents a method for rapid antibiotic susceptibility testing and species identification in mixed infections using microfluidic chips and in situ FISH.

Hepatic Leukemia Factor supports the propagation of leukemia and hematopoietic stem cell function during stress-induced regeneration.

This study shows HLF is essential for stress-induced hematopoietic regeneration and leukemia propagation in aged HSCs but not for normal aging hematopoiesis.

Disruption of a GATA2, TAL1, ERG regulatory circuit promotes erythroid transition in healthy and leukemic stem cells

The paper identifies a GATA2, TAL1, ERG regulatory circuit that promotes erythroid transition in both healthy and leukemic stem cells, showing its persistence in AML with minor alterations.

Live cell imaging reveals that RecA finds homologous DNA by reduced dimensionality search

The paper uses live cell imaging to show that RecA filaments in E. coli find homologous DNA through a two-dimensional search mechanism, completing DSB repair within 15 minutes.

Paladin is a PI(4,5)P2 phosphoinositide phosphatase that regulates endosomal signaling and angiogenesis

A time-resolved imaging-based CRISPRi screening method

This paper introduces a CRISPRi screening method combining time-lapse imaging and microfluidic devices to study gene knockdown effects on E. coli cell cycle dynamics.

Not dead yet: Diatom resting spores can survive in nature for several millennia.

This paper revives ancient diatom resting spores up to 7200 years old and extracts DNA to study long-term environmental adaptation.