A. Backstrom

Subcellular mapping of the protein landscape of SARS-CoV-2 infected cells for target-centric drug repurposing

The paper uses immunofluorescence to analyze host protein changes in SARS-CoV-2 infection and identifies three drugs that reduce antiviral activity.

Inducing synthetic lethality for selective targeting of acute myeloid leukemia cells harboring STAG2 mutations

This study demonstrates that partial STAG1 perturbation selectively kills STAG2-mutated AML cells while sparing normal HSCs, showing synthetic lethality in xenograft models.

Large ecological benefits of small urban greening actions

The paper shows that small urban greening actions can lead to significant ecological benefits, including increased insect diversity and community interactions within three years.

Indigenous plants promote insect biodiversity in urban greenspaces

This study shows that indigenous plants, especially graminoids, support higher insect biodiversity in urban greenspaces compared to nonnative species.

Spatiotemporal dissection of the cell cycle with single-cell proteogenomics

The paper maps spatiotemporal proteomic heterogeneity during the cell cycle using single-cell proteogenomics and identifies 235 cell cycle-associated proteins.

A sample preparation protocol for high throughput immunofluorescence of suspension cells

This paper presents a protocol for high-throughput immunofluorescence of suspension cells, enabling systematic protein localization analysis in hematopoietic cells.