Machine learning engineered PoLixNano nanoparticles overcome delivery barriers for nebulized mRNA therapeutics
Dandan Zhang, Qin Xiao, Jie Tang, Kai Xiao, Tingting Chen, Chen Yang, Yuheng Liu, Lifeng Xu, Chao Li, Larry Cai, Shouyuan Huang, Ying Wang, Liusheng Peng, Joseph Rosenecker, Dan Shao, , Shan Guan
The paper develops PoLixNano nanoparticles using machine learning to enhance mRNA delivery through nebulization, achieving high transfection efficiency and therapeutic efficacy in animal models.
bioRxiv · Nov 3, 2024 · PreprintSynthetic Biology