Cytosolic transport of citrate protects nutrient-austere pancreatic cancer from ferroptosis
Adam Kneebone, Kailey Lindaur, Ata Abbas, Joel A. Cassel, Sarah Graff, Gerard J. Abood, Xianzhong Ding, William Small, Curtis M. Tatsuoka, Simone Sidoli, Joseph M. Salvino, Ali Vaziri Gohar
This study identifies SLC25A1-mediated citrate transport as a mechanism protecting pancreatic cancer cells from ferroptosis under nutrient stress, with therapeutic implications for PDAC.
bioRxiv · Jan 15, 2025 · PreprintCancer Biology