Redundant roles of YES and SRC tyrosine kinases in driving malignant peripheral nerve sheath tumors
Elamine Zereg, Laure Voisin, Mathieu Courcelles, Sylvie Brochu, Melania Gombos, Éric Bonneil, Karl Grenier, Sungmi Jung, Claude Perreault, Franck Tirode, Pierre Thibault, Sylvain Meloche
This study identifies YES and SRC tyrosine kinases as redundant drivers of MPNST and shows their inhibition suppresses tumor growth and reactivates immune responses.
bioRxiv · Feb 20, 2026 · PreprintCancer Biology