Gergely L. Lukács

This study investigates how the human mitochondrial processing peptidase (MPP) recognizes and processes the N-terminal targeting sequence of PINK1, revealing its binding mechanism and functional implications.

This study identifies HERC3 as a cytosolic E3 ligase that facilitates ERAD of specific polytopic membrane proteins like CFTR, distinct from RNF5/185.

The paper evaluates AlphaMissense's performance in predicting pathogenicity of missense variants across diverse protein groups and introduces a web resource for access.

The paper shows that allosteric domain-domain coupling modulates the folding landscape of ABCC transporters, and that folding correctors can rescue misfolding by rewiring these networks.

This study evaluates AlphaFold2's performance in predicting transmembrane protein structures and finds it highly accurate even for TM proteins.