Multiomic profiling reveals pericyte and smooth muscle cell contributions to CADASIL pathology in cell-specific Notch3 mutant mice
Yazi Huang, Veronica A. Clementel, Mingzi Zhang, Kate Martinez, Karen Martinez, Gavin Spillard, Carina Torres-Sepulveda, Kassandra Kisler, Marcelo P. Coba, Ruslan Rust
This study uses mouse models to show that Notch3 mutations in pericytes and smooth muscle cells cause distinct vascular and neuroinflammatory changes in CADASIL.
Cell Reports · Apr 1, 2026Peer-reviewedNeuroscience