Global ribosome profiling reveals that mutant huntingtin stalls ribosomes and represses protein synthesis independent of fragile X mental retardation protein
Mehdi Eshraghi, Pabalu P. Karunadharma, Juliana Blin, Neelam Shahani, Emiliano P. Ricci, Audrey M. Michel, Nicolai T. Urban, Nicole Galli, Sumitha Rajendra Rao, Manish Sharma, Katie Florescu, Srinivasa Subramaniam
This study shows mutant huntingtin (mHtt) stalls ribosomes and suppresses protein synthesis independently of FMRP, using ribosome profiling in HD cells and mouse models.
bioRxiv · May 7, 2019 · PreprintNeuroscience