Loss of B cell tolerance at the T2/T3a B cell transition is a convergent pathogenic mechanism in common variable immunodeficiency
Kirsty Hillier, Grace J. Yuen, Anson Hui, Suparna Kumar, Priyamvada Guha Roy, Joseph T. McColgan, Kimberly S. Zaldana, Hugues Allard‐Chamard, Katie Premo, Naoki Kaneko, Nicole Ingram, Sara Barmettler, Musie S Ghebremichael, Jolan Eszter Walter, Cory A. Perugino, , Shiv S Pillai
The paper identifies loss of transitional B cell tolerance and extrafollicular expansion of autoreactive B cells as a common mechanism driving autoimmunity in monogenic CVID.
bioRxiv · Jun 7, 2025 · PreprintImmunology