Grace J. Yuen

This study identifies a core gene program underlying Tfh cell differentiation using a multi-scale network systems approach, revealing a novel role for IL-12 in regulating Tfh precursor differentiation.

The paper identifies loss of transitional B cell tolerance and extrafollicular expansion of autoreactive B cells as a common mechanism driving autoimmunity in monogenic CVID.

Congenital T cell activation in CTLA4-deficient patients impairs transitional to follicular B cell maturation and can be rescued by CTLA4 replacement therapy in vivo.