Hardwired synthetic lethality within the cohesin complex in human cancer cells
Petra van der Lelij, Simone Lieb, Julian Jude, Gordana Wutz, Catarina P. Santos, Katrina Falkenberg, Andreas Schlattl, Jozef Ban, Raphaela Schwentner, Heinrich Kovar, Francisco X. Real, Todd Waldman, Mark A. Pearson, Norbert Kraut, Jan-Michael Peters, , Mark Petronczki
This study identifies a synthetic lethal interaction between STAG1 and STAG2 in cancers with STAG2 mutations, suggesting STAG1 as a therapeutic target.
bioRxiv · Apr 8, 2017 · PreprintCell Biology