Structural ubiquitin contributes to K48 linkage-specificity of the HECT ligase Tom1
Katrina Warner, Moritz Hunkeler, Kheewoong Baek, Anna M. Schmoker, Shourya S. Roy Burman, Daan Overwijn, Cyrus Y. Jin, Katherine A. Donovan, Eric S. Fischer
The paper shows that structural ubiquitin contributes to K48 linkage-specificity in Tom1 through a non-canonical binding site identified via cryo-EM.
Cell Reports · May 1, 2025Peer-reviewedBiochemistry