Osmotic Coupling of Mechanics and Epigenetics Regulates Chromatin Phase Organization
Aayush Kant, Monika Dhankhar, Rohit Joshi, Zixian Guo, Vinayak Vinayak, Diana Isabel Cruz, Kedi Wang, Ivan Vladimirovich Surovtsev, Megan King, Abhijit Majumder, Jung-Hwan Lee, Hae-Won Kim, Elizabeth Hinde, Guilherme P. F. Nader, Vivek B. Shenoy
This study develops a model linking nuclear hydration to chromatin phase organization and mechanics, showing how osmotic and mechanical cues influence chromatin structure through water content and histone dynamics.
bioRxiv · Oct 30, 2026 · PreprintBiophysics