Phosphorylated -Synuclein shapes changes in brain structure, task-related activity and functional connectivity in M83 mice
Amr Eed, Vladislav Novikov, Shahrzad Bahrampour, Kelly Summers, Stéphanie Tullo, Mallar Chakravarty, Wen Luo, Irina Shlaifer, Thomas M. Durcan, Vânia F. Prado, Ali R. Khan, Marco A. M. Prado, Ravi S. Menon
This study shows that pS129 accumulation in M83 mice leads to structural atrophy, reduced functional connectivity, and hypoactivation in somatosensory areas.
bioRxiv · Sep 22, 2026 · PreprintNeuroscience