Kelsey Bernard

Neuroprotective activity of sub-anesthetic ketamine in a preclinical model of Parkinson's disease is not blocked by antagonizing brain-derived neurotrophic factor signaling

This study shows that low-dose ketamine protects against Parkinson's-like motor deficits in rats without relying on BDNF-TrkB signaling.

Acute E2/P4 loss compromises the biology and function of neurogenic niches during a vulnerable female aging period

This study shows that loss of estradiol and progesterone in female rats at 9 months of age reduces neurogenesis and behavioral function, earlier than age-related declines at 14 months.

Bioenergetic and Protein Processing Imbalances Synergize in iPSC-Dopamine neurons from Individuals with Idiopathic Parkinsons Disease

This study examines bioenergetic and protein processing defects in iPSC-derived dopamine neurons from idiopathic Parkinson's disease patients, revealing impaired mitochondrial function and alpha synuclein aggregation.

The 5-HT1F Receptor Agonist Lasmiditan improves Cognition and Ameliorates Associated Cortico-Hippocampal Pathology in Aging Parkinsonian Mice

This study shows that lasmiditan, a 5-HT1F receptor agonist, improves cognition and reduces pathology in aging Parkinsonian mice by enhancing mitochondrial biogenesis and reducing alpha-synuclein aggregation.

Parallel Neurodegenerative Phenotypes in Sporadic Parkinsons Disease Fibroblasts and Midbrain Dopamine Neurons

The paper identifies parallel neurodegenerative phenotypes in fibroblasts and iPSC-derived dopamine neurons from sporadic Parkinson's disease patients, revealing shared and distinct molecular and cellular alterations.