Comparative effects of central and peripheral PDE10A inhibition on weight gain following semaglutide cessation in diet-induced obese mice
James F E Grey, Bradleigh Whitton, Kenneth Mulvaney
This study compares the effects of central and peripheral PDE10A inhibition on weight gain after stopping semaglutide in obese mice, finding that central inhibition is more effective.
bioRxiv · Sep 14, 2026 · PreprintPharmacology & Toxicology