Ferroptotic vulnerability of post-meiotic germ cells skews sex chromosome ratios in aged testis
Jasper Germeraad, Takako Kikkawa, Junya Ito, Leon S.Y. Giesselink, Wilfred T.V. Germeraad, Bernhard Henkelmann, Maceler Aldrovandi, Kenshiro Hara, Kentaro Tanemura, Kiyotaka Nakagawa, Eikan Mishima, Marcus Conrad, Noriko Osumi
This study shows that aging increases ferroptotic vulnerability in round spermatids, leading to a Y-chromosome skew in sperm, which can be modulated by vitamin E.
bioRxiv · Oct 21, 2024 · PreprintMolecular Biology