Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter
Kevin L. Jagessar, Samantha L. Gies, Tianqi Wu, Ian Miller, Khadijeh Dastvan, Reza Dastvan
The paper investigates the mechanism of proton-coupled transport in the mycobacterial Spns transporter using spectroscopy, modeling, and mutagenesis, revealing how protonation and substrate binding influence conformational states and transport directionality.
bioRxiv · Jul 6, 2026 · PreprintBiophysics