SLC33A1 exports oxidized glutathione to maintain endoplasmic reticulum redox homeostasis
Shanshan Liu, Mark Gad, Caifan Li, Kevin Cho, Yuyang Liu, Khando Wangdu, Viktor Belay, Alon Millet, Hiroyuki Kojima, Henry Sanford, Michele Wölk, Linas Urnavicius, Maria Fedorova, Gary J. Patti, Ekaterina V. Vinogradova, , Kıvanç Birsoy
This study identifies SLC33A1 as the major ER GSSG exporter, showing its role in maintaining ER redox balance and protein maturation through direct GSSG transport and regulation of PDIs.
Nature Cell Biology · Apr 17, 2026Peer-reviewedCell Biology