Alpaslan Tasdogan

This study shows that MCT1-mediated lactate uptake sustains nucleotide homeostasis in NSCLC, and its inhibition enhances chemotherapy efficacy by exposing a metabolic vulnerability.

SIMO integrates spatial metabolomics, lipidomics, and proteomics from a single tissue section to enable comprehensive multi-omics analysis across spatial regions.

This study shows that L-2HG accumulation due to L2HGDH deficiency impairs neuronal differentiation by epigenetically activating MYC, leading to stem cell self-renewal and reduced neuron formation.

This study identifies polyamines as key regulators of epithelial regeneration in aged intestines, showing they enhance protein homeostasis and restore regenerative capacity through dietary manipulation.

This study identifies genotype-specific mitochondrial metabolic vulnerabilities in liver cancer and shows that phosphatidylethanolamine synthesis contributes to immune evasion.

This study shows autophagy is essential for maintaining HEV function and expansion during inflammation, ensuring proper PNAd production and lymphocyte homing.

This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.

This study identifies KDM5B's role in regulating the PRDX/TXN ROS detoxification system in melanoma DTPs, showing that PRDX inhibition increases ROS vulnerability and delays resistance to MAPK inhibition.

This study shows that mast cell deficiency does not impair immunological protection against sepsis, as Kit-mutant mice are as resistant as wild-type mice, with susceptibility instead due to intestinal dysbiosis.

This study shows that pathogenic mtDNA mutations in melanoma cells reduce metastasis by limiting circulation entry, despite promoting tumor growth.

This study identifies integrin alpha11 as the receptor for Osteolectin, showing its role in osteogenic differentiation and bone mass maintenance through Wnt pathway activation.