Aging increases ovarian cancer growth, metastasis, and immunosuppression that can be alleviated by inhibiting hedgehog signaling
Asha Kumari, Mohamed Halaby Elbahoty, Resha Rajkarnikar, Khushi Sureja, Manan Virendra Nayyar, Mehri Monavarian, Liz Quintero-Macías, Katherine Cynthia Fuh, Daniel J. Tyrrell, Lalita A. Shevde, Sudarshan Anand, Camilla Margaroli, Karthikeyan Mythreye
This study shows aging promotes ovarian cancer growth and immunosuppression, which can be mitigated by inhibiting Hedgehog signaling in mice and correlates with immune checkpoint resistance in humans.
bioRxiv · Jul 2, 2026 · PreprintCancer Biology