The E525K β-Myosin Mutation Causes Hypocontractility in Cardiomyocytes Without Altering Crossbridge Cycling
Kalen Z. Robeson, Timothy S. McMillen, Kristina Bezold Kooiker, Kerry Y. Kao, Travis Carver Tune, Kieran Frebis, Michael A. Geeves, Andrew P. Wescott, Rachelle Soriano, Alex J. Goldstein, Matthew Carter Childers, Rama Reddy Goluguri, Divya Pathak, Åshild Telle, Iselin Crosby, , Michael Regnier
This study shows that the E525K β-myosin mutation reduces cardiomyocyte contraction without altering crossbridge cycling, through structural and computational analysis.
bioRxiv · Oct 22, 2026 · PreprintBiophysics