Polyglutamine aggregation in the C. elegans nervous system is driven by stochastic nucleation events
Vera van Schijndel, Jorieke Tiggelaar, Myrthe S. E. Franken, Delano Remkes, Maithili Joshi, Deep Sandhu, Klaske Baars, Jesse D. F. de Graaf, Tessa Sinnige
This study shows polyglutamine aggregation in C. elegans neurons occurs through stochastic nucleation, independent of cellular context and ageing.
bioRxiv · Oct 26, 2026 · PreprintBiophysics