The Nkx2.3-Nr5a1 gene cascade plays a crucial role in spleen-specific vascular architecture and marginal zone formation
Kanako Miyabayashi, Koji Ono, Tetsuya Sato, Ayano Yahagi, Masanori Iseki, Katsuhiko Ishihara, Takami Mori, 実紀 井上, Ryuki Shimada, Kei‐ichiro Ishiguro, Tomohiro Ishii, Jongsung Noh, Man Ho Choi, Takashi Baba, Yasuyuki Ohkawa, , Yuichi Shima
This study identifies an Nkx2.3-Nr5a1 gene regulatory axis critical for spleen-specific vascular architecture and marginal zone formation in mice.
bioRxiv · Feb 10, 2026 · PreprintDevelopmental Biology