Spatial multiomic profiling reveals distinct fibrotic epithelial niches in idiopathic pulmonary fibrosis
Bin Liu, Konain Bhatti, Iain D. Stewart, James Michael May, Maria Concetta Zarcone, Nathalie Lambie, Nik Matthews, Rachel L. Clifford, Charlotte H. Dean, Peter Myles George, Richard J Hewitt, Elena Ana López-Jiménez, Maddy Parsons, Simon R. Johnson, Anna K. Reed, , Alison E. John
The paper uses spatial multiomic profiling to identify distinct fibrotic epithelial niches in IPF, revealing a KRT5low/KRT17 epithelial population and its association with SPP1 macrophages.
bioRxiv · Dec 10, 2024 · PreprintMolecular Biology