Enhanced Radio-sensitization of Glioblastoma using a Dendrimer-Based Metformin Nano-formulation through Direct Tumor Suppression and Indirect Immune Modulation
Sadaf Mahfooz, Fei Wang, Ghanbar Mahmoodi Chalbatani, Tatiana K. Bronich, Svetlana Romanova, yuanyuan Jia, Krishna Bhat, Chi Zhang
This study develops a dendrimer-based metformin nano-formulation (P4-MET) that enhances GBM treatment by improving drug delivery, modulating ferroptosis pathways, and synergizing with radiotherapy.
bioRxiv · May 17, 2026 · PreprintCancer Biology