Fei Wang

Stromal control of sympathetic rewiring in metastatic lymph nodes

This study shows that tumor-driven remodeling of metastatic lymph nodes involves sympathetic neural rewiring mediated by stromal HGF and mechanical cues.

Charting sex divergence in the human brain across the lifespan

This paper constructs sex-specific lifespan brain charts using neuroimaging data from 59,915 individuals, revealing dynamic sex differences in brain development and improving detection of neuropsychiatric abnormalities.

Confronting spurious evaluations of computational methods in small molecule mass spectrometry

The paper exposes a flaw in evaluating small molecule MS/MS models by showing trivial models can perform well due to dataset biases and proposes a new benchmark to assess true model capability.

Drosophila melanogaster Nepl15 gene deletion promotes anti-aging and anti-obesity phenotypes in a sex-dependent manner

This study shows that deleting the Nepl15 gene in Drosophila improves anti-aging and anti-obesity traits, with stronger effects in females than males.

Enhanced Radio-sensitization of Glioblastoma using a Dendrimer-Based Metformin Nano-formulation through Direct Tumor Suppression and Indirect Immune Modulation

This study develops a dendrimer-based metformin nano-formulation (P4-MET) that enhances GBM treatment by improving drug delivery, modulating ferroptosis pathways, and synergizing with radiotherapy.

Haplotype-resolved genome assembly advances genetic understanding of trait diversity in Phalaenopsis orchids

This study presents a haplotype-resolved genome for Phalaenopsis orchids, revealing genetic factors underlying trait diversity such as lip morphology and color patterns.

A reconfigurable DNA memory architecture for hierarchical data management via programmable phase transitions

This paper introduces a reconfigurable DNA memory architecture that enables hierarchical data management through programmable phase transitions, achieving high storage density and stability.

A human gut-BBB-brain microphysiological model for studying neurodegenerative diseases

This paper develops a human gut-BBB-brain microphysiological model to study neurodegenerative diseases and finds that gut-brain interactions can promote brain organoid maturation and recapitulate AD pathology.

Subgenual Anterior Cingulate Cortex Functional Connectivity Abnormalities in Depression: Insights from Brain Imaging Big Data and Precision-Guided Personalized Intervention via Transcranial Magnetic Stimulation

The paper identifies sgACC functional connectivity abnormalities in depression using large-scale brain imaging data and develops an individualized TMS targeting algorithm to improve treatment outcomes.

Functional connectome through the human life span

The paper analyzes functional and structural MRI data from 33,250 individuals to map lifespan changes in the functional connectome, identifying key developmental stages and differences in neurological disorders.

Direct preparation of Cas9 ribonucleoprotein from E. coli for PCR-free seamless DNA assembly

The paper describes a method to directly prepare Cas9 RNP from E. coli for PCR-free DNA assembly with high fidelity.

Cycloserine for Treatment of Multidrug-Resistant Tuberculosis in China: A Retrospective Observational Study

This study evaluates cycloserine's efficacy and safety in treating MDR-TB in China, finding it improves outcomes for simple MDR-TB but not pre-XDR-TB or XDR-TB.