Cigarette smoke and biological age induce degenerative heterogeneity in retinalpigment epithelium
Krishna Singh, Yang Oh Jin, Ming-Wen Hu, Isabella Palazzo, Marisol Cano, Thanh V. Hoang, Imran Ahmed Bhutto, Shusheng Wang, Debasish Sinha, Seth Blackshaw, Jiang X. Qian, James T. Handa
This study shows cigarette smoke and aging induce degenerative heterogeneity in RPE cells through distinct epigenetic changes, with young RPE showing compensatory responses not seen in aged RPE.
bioRxiv · Jan 27, 2025 · PreprintNeuroscience