Pan-Cancer Analysis Reveals Technical Artifacts in The Cancer Genome Atlas (TCGA) Germline Variant Calls
Alexandra R. Buckley, Kristopher A. Standish, Kunal Bhutani, Trey E. Ideker, Roger S. Lasken, Hannah K. Carter, Olivier Harismendy, Nicholas J. Schork
This study identifies technical artifacts in TCGA germline variant calls, showing how batch effects from DNA amplification confound germline-tumor type associations and recommends removing amplified DNA samples.
BMC Genomics · Jun 12, 2017Peer-reviewedGenomics