Author

Roger S. Lasken

J. Craig Venter Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Assay:scRNA-seq· 4 Approach:statistical model· 4 Research Focus:batch correction / integration· 1 Research Focus:clustering· 1 Approach:machine learning (classical)· 1 Organism:mouse· 1

Frequent Co-Authors

Brian D. AevermanniD· 4 shared Ed S. LeiniD· 4 shared Jeremy A. MilleriD· 4 shared Nicholas J. SchorkiD· 4 shared Richard H. ScheuermanniD· 4 shared Trygve E. BakkeniD· 4 shared Kimberly A. SmithiD· 3 shared Mark A. NovotnyiD· 3 shared

Activity by Year

2017-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersNeuroscience

Brian D. AevermannORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons

Rebecca D. Hodge, Jeremy A. Miller, Mark A. Novotny, Brian E. Kalmbach, Jonathan T. Ting, Trygve E. Bakken, Brian D. Aevermann, Eliza R. Barkan, Madeline L. Berkowitz-Cerasano, Charles Cobbs, Francisco Díez‐Fuertes, Song‐Lin Ding, Jamison McCorrison, Nicholas J. Schork, Soraya I. Shehata, , Ed S. Lein

The paper identifies von Economo neurons as a regionally specialized subtype of extratelencephalic-projecting excitatory neurons using single nucleus RNA-sequencing and cross-species comparisons.

Nature Communications · Mar 3, 2020Peer-reviewedNeuroscience

Equivalent high-resolution identification of neuronal cell types with single-nucleus and single-cell RNA-sequencing

Trygve E. Bakken, Rebecca D. Hodge, Jeremy A. Miller, Zizhen Yao, Thuc Nghi Nguyen, Brian D. Aevermann, Eliza R. Barkan, Darren Bertagnolli, Tamara Casper, Nick Dee, Emma J. Garren, Jeff Goldy, Lucas T. Graybuck, Matthew Kroll, Roger S. Lasken, , Bosiljka Tasic

The paper shows that single-nucleus and single-cell RNA-seq can equally identify neuronal cell types in mouse visual cortex when intronic sequences are included.

PLoS ONE · Dec 26, 2018Peer-reviewedNeuroscience

Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type

Eszter Boldog, Trygve E. Bakken, Rebecca D. Hodge, Mark A. Novotny, Brian D. Aevermann, Judith Baka, Sándor Bordé, Jennie Close, Francisco Díez‐Fuertes, Song‐Lin Ding, Nóra Faragó, Ágnes K. Kocsis, Balázs Kovács, Zoe Maltzer, Jamison McCorrison, , Gábor Tamás

The paper identifies a novel human cortical GABAergic interneuron subtype with unique transcriptomic, morphological, and physiological features not observed in rodents.

Nature Neuroscience · Aug 20, 2018Peer-reviewedNeuroscience

Big data and single cell transcriptomics: implications for ontological representation

Brian D. Aevermann, Mark A. Novotny, Trygve E. Bakken, Jeremy A. Miller, Alexander D. Diehl, David Osumi-Sutherland, Roger S. Lasken, Ed S. Lein, Richard H. Scheuermann

The paper reviews how single cell RNA sequencing is identifying new human cell types and proposes a machine learning method to improve cell type definitions in the Cell Ontology.

Human Molecular Genetics · Mar 23, 2018Peer-reviewedBioinformatics

Pan-Cancer Analysis Reveals Technical Artifacts in The Cancer Genome Atlas (TCGA) Germline Variant Calls

Alexandra R. Buckley, Kristopher A. Standish, Kunal Bhutani, Trey E. Ideker, Roger S. Lasken, Hannah K. Carter, Olivier Harismendy, Nicholas J. Schork

This study identifies technical artifacts in TCGA germline variant calls, showing how batch effects from DNA amplification confound germline-tumor type associations and recommends removing amplified DNA samples.

BMC Genomics · Jun 12, 2017Peer-reviewedGenomics