Light-regulated SIK1 remodels the synaptic phosphoproteome to induce sleep
Lewis Taylor, Teele Palumaa, Paul Kirkpatrick Reardon, Steven Walsh, Bradley Johnson, Sabrina Liberatori, Sibah Hasan, Kristopher Clark, Philip Cohen, Sridhar R. Vasudevan, Stuart N. Peirson, Shabaz Mohammed, Vladyslav V. Vyazovskiy, F. Foster, Aarti Jagannath
This study shows that SIK1 activity modulates synaptic phosphoproteome to induce sleep independently of sleep pressure, revealing a causal mechanism for sleep regulation.
bioRxiv · Sep 28, 2021 · PreprintNeuroscience