Targeting the WSB2-NOXA Axis in Cancer Cells for Enhanced Sensitivity to BCL-2 Family Protein Inhibitors
Dongyue Jiao, Kun Chang, Jiamin Jin, Yingji Chen, Ren Mo, Yucong Zhang, Kun Gao, Yaoting Xu, Lixin Wang, Chenji Wang
This study identifies WSB2 as a regulator of mitochondrial apoptosis and shows that targeting the WSB2-NOXA axis enhances sensitivity to BCL-2 inhibitors in cancer cells.
eLife · Aug 7, 2024Peer-reviewedCell Biology