AI-driven discovery and engineering of human endogenous nanocage proteins for mRNA delivery
Dongmin Xun, Lanqing Li, Jie Zou, Yi Liu, Ziyue Yang, Qianyi Liang, Ke Li, Zhu Zhu, Jicong Zhang, Lijun Lang, Kun Liu, Xinyu Wang, Meilin Tian, Guangyong Chen, Bolin An, , Chao Zhong
The paper develops DeepDelivery, an AI platform that identifies human proteins for mRNA delivery, validating 80% of top candidates for efficient, non-inflammatory delivery.
Nature Communications · Oct 31, 2026Peer-reviewedSynthetic Biology