Ning Wang

Structural insights and engineering of deep-sea halophilic PET hydrolytic enzymes

The paper structures and engineers deep-sea halophilic PET hydrolases to improve their salt tolerance and catalytic efficiency for industrial applications.

BiomniBench: Process-level Evaluation of LLM Agents for Real-world Biomedical Research

BiomniBench evaluates LLM agents' research processes in biomedical tasks using expert rubrics, revealing performance gaps in method selection and reasoning.

Distinguish risk genes functioning at presynaptic or postsynaptic regions and key connectomes associated with pathological α-synuclein spreading

The paper identifies presynaptic and postsynaptic risk genes and key connectomes involved in pathological α-synuclein spreading using mathematical models and gene regulatory network analysis.

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

This study shows T4 treatment alters cell-type specific genes, pathways, and networks in hippocampus and frontal cortex after mTBI, reversing mTBI-affected genes and pathways.

DNA methylation patterns of transcription factor binding regions characterize their functional and evolutionary contexts

The paper identifies DNA methylation patterns at TF binding sites across species, linking them to functional roles and evolutionary changes.

Nutrient restriction, inducer of yeast meiosis, induces mammalian meiosis

Nutrient restriction synergizes with retinoic acid to induce mammalian meiotic initiation.

Regulatory B cells contribute to the alleviation of colitis induced by Dextran Sulphate Sodium after H.pylori infection

This study shows that Helicobacter pylori infection reduces colitis severity in DSS-treated mice by increasing anti-inflammatory Breg cells.