Jade1S SUMOylates tau and targets oligomers for degradation
Soong Ho Kim, Vanessa L Stahl, Lyucheng Zou, Samin Hassan, Herbert T Cohen, Kurt Farrell, Richard W Vachet, Jennifer N Rauch, John F Crary
This study identifies Jade1S as a SUMO ligase and chaperone that regulates tau stability, prevents oligomerization, and promotes proteasomal degradation of aggregated tau.
bioRxiv · Nov 5, 2026 · PreprintBiochemistry