BiochemistrybioRxivPreprint
Jade1S SUMOylates tau and targets oligomers for degradation
Soong Ho Kim, Vanessa L Stahl, Lyucheng Zou…·John F Crary
This study identifies Jade1S as a SUMO ligase and chaperone that regulates tau stability, prevents oligomerization, and promotes proteasomal degradation of aggregated tau.
DOI 10.64898/2026.11.03.764021