Network analysis of mouse brain proteomes resolves molecular and cellular endophenotypes of aging and Aβ pathology
Sruti Rayaprolu, Sneha Malepati, Eric B. Dammer, Kyla Langdon, Rashmi Kumari, Amanda D. Brandelli, Claudia Espinosa-Garcia, Duc D. Duong, Upasna Srivastava, Prateek Kumar, Ali Tfaily, Jiahui Chen, Xin Zhou, Yinlong Li, Ahmad F. Chaudhary, , Srikant Rangaraju
This study uses proteomics to identify aging and Aβ-related molecular changes in mouse brains and finds they are conserved in human AD proteomes.
bioRxiv · Nov 6, 2026 · PreprintNeuroscience