Angiogenic CD8 T cells from PWH induce Granzymes-dependent PAR1 activation promoting endothelial inflammation
Tong Li, Chinmayee Mehta, Cooper James, Jinya Chen, Hui Chen, Gerard P. Ahern, Ziang Zhu, Maitane Faus Cid, Maryam Abdussamad, Shiwen Yu, Jai Kumar, Princy N. Kumar, Colleen M. Hadigan, Kyle A. DiVito, Dorian B. McGavern, , Marta Catálfamo
The paper identifies CD8 T cells in HIV-positive individuals that promote endothelial inflammation via granzyme-dependent PAR1 activation, linking immune activation to cardiovascular risk.
bioRxiv · Aug 6, 2025 · PreprintImmunology