GPR68, a proton-sensing GPCR, mediates acid-induced visceral nociception
Luke W Paine, Rohit Gupta, James P. Higham, Javier Aguilera‐Lizarraga, Anne Ritoux, Pritchard, Thomas, M.A., Samuel J. Nicholson, James R.F. Hockley, Tim Raine, Martin Hausmann, Kyle Bednar, Gerhard Rogler, Fraser Welsh, Ewan St John Smith, David Colin Bulmer
This study identifies GPR68 as a mediator of acid-induced colonic nociception through genetic and pharmacological approaches in mice.
Cellular and Molecular Gastroenterology and Hepatology · Jan 1, 2026Peer-reviewedNeuroscience