Single-cell analysis of brain-derived Toxoplasma bradyzoites reveals a novel cell cycle regulated by AP2XI-6.
Emma Franklin, Argenis Arriojas, Kyra Lee, Grace Hilliard, Bruno Martorelli Di Genova, Gary E. Ward, Kourosh Zarringhalam, Robyn S. Kent
The paper uses single-cell RNA profiling to show in vivo-derived Toxoplasma bradyzoites undergo two cell cycles, with AP2XI-6 playing a key role in one cycle essential for cyst maturation.
bioRxiv · Oct 20, 2025 · PreprintMicrobiology