A CRISPR-Based Humanized Model Reveals Cooperative Role of STAG2 Loss in Familial GATA2-Deficient MDS Progression
Grace S. Freed, Miguel Quijada Álamo, L Lee, Ke Wang, Nikita Poddar, Subrina Persaud, Saul Carcamo, Persephone Fiore, Emma K Kim, Isabella G. Martinez, Mimi Zhang, Shayan Saniei, Clifford Chao, Levan Mekerishvili, Zayna Diaz, , Elvin Wagenblast
This paper uses a CRISPR-based humanized model to show that STAG2 loss cooperates with GATA2 deficiency to drive MDS progression through increased HSC self-renewal and myeloid bias.
Blood Advances · Sep 24, 2026Peer-reviewedCancer Biology