The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants
S. Gellenoncourt, N. Saunders, R. Robinot, L. Auguste, M. M. Rajah, J. Kervevan, R. Jeger-Madiot, I. Staropoli, C. Planchais, H. Mouquet, J. Buchrieser, O. Schwartz, L. A. Chakrabarti
This study shows the D614G mutation enhances the infectious potential of SARS-CoV-2 variants by synergizing with cleavage site mutations like P681H/R to increase spike fusogenicity.
bioRxiv · May 20, 2022Microbiology