Author

N. Saunders

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 5 Assay:proteomics· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

O. Schwartz· 6 shared J. Buchrieser· 5 shared C. Planchais· 4 shared H. Mouquet· 4 shared D. Planas· 3 shared F. Porrot· 3 shared I. Staropoli· 3 shared W. H. Bolland· 3 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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6 shared papersMicrobiology

O. Schwartz

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Structural basis of TMPRSS2 zymogen activation and recognition by the HKU1 seasonal coronavirus

I. Fernandez, N. Saunders, S. Duquerroy, W. H. Bolland, A. Arbabian, E. Baquero, C. Blanc, P. Lafaye, A. Haouz, J. Buchrieser, O. Schwartz, F. A. Rey

This study determines the structure of HKU1-CoV receptor binding domain in complex with TMPRSS2, identifying key residues for host tropism and revealing the structural basis of TMPRSS2 activation.

bioRxiv · Feb 21, 2024Biochemistry

Dynamic label-free analysis of SARS-CoV-2 infection reveals virus-induced subcellular remodeling.

N. Saunders, B. Monel, N. Cayet, L. Archetti, H. Moreno, A. Jeanne, A. Marguier, T. Wai, O. Schwartz, M. Frechin

This study uses AI and label-free microscopy to analyze subcellular changes in SARS-CoV-2 infected cells, revealing organelle remodeling and cross-regulation networks.

bioRxiv · Nov 16, 2023Cell Biology

The spike-stabilizing D614G mutation interacts with S1/S2 cleavage site mutations to promote the infectious potential of SARS-CoV-2 variants

S. Gellenoncourt, N. Saunders, R. Robinot, L. Auguste, M. M. Rajah, J. Kervevan, R. Jeger-Madiot, I. Staropoli, C. Planchais, H. Mouquet, J. Buchrieser, O. Schwartz, L. A. Chakrabarti

This study shows the D614G mutation enhances the infectious potential of SARS-CoV-2 variants by synergizing with cleavage site mutations like P681H/R to increase spike fusogenicity.

bioRxiv · May 20, 2022Microbiology

Fusogenicity and neutralization sensitivity of the SARS-CoV-2 Delta sublineage AY.4.2

N. Saunders, D. Planas, W. H. Bolland, C. Rodriguez, S. Fourati, J. Buchrieser, C. Planchais, M. Prot, I. Staropoli, F. Guivel-Benhassine, F. Porrot, D. Veyer, H. Pere, N. Robillard, M. Saliba, , O. Schwartz

This study examines the fusogenicity and neutralization sensitivity of the SARS-CoV-2 AY.4.2 sublineage compared to the Delta variant, finding similar spike function but reduced neutralization sensitivity to certain antibodies and vaccines.

bioRxiv · Jan 7, 2022Microbiology

Considerable escape of SARS-CoV-2 variant Omicron to antibody neutralization

D. Planas, N. Saunders, P. Maes, F. G. Benhassine, C. Planchais, F. Porrot, I. Staropoli, F. Lemoine, H. Pere, D. Veyer, J. Puech, J. Rodary, W. H. Bolland, J. Buchrieser, G. Baele, , O. Schwartz

This study shows that the Omicron variant of SARS-CoV-2 is resistant to most monoclonal antibodies and vaccine-induced antibodies, with reduced neutralization compared to Delta.

bioRxiv · Dec 14, 2021Immunology

SARS-CoV-2 Alpha, Beta and Delta variants display enhanced Spike-mediated Syncytia Formation

M. M. Rajah, M. Hubert, E. Bishop, N. Saunders, R. Robinot, L. Grzelak, D. Planas, J. Dufloo, S. Gellenoncourt, A. Bongers, M. Zivaljic, C. Planchais, F. Guivel-Benhassine, F. Porrot, H. Mouquet, , O. Schwartz

This study compares syncytia formation by SARS-CoV-2 Alpha, Beta, and Delta variants to D614G, finding enhanced fusogenicity and differential effects of mutations on ACE2 binding and antibody escape.

bioRxiv · Jun 11, 2021Microbiology