Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning
L. Beunk, S. van Helvert, B. Bekker, L. Ran, R. Kang, T. Paulat, S. Syga, A. Deutsch, P. Friedl, K. Wolf
This study shows that matrix density and guidance cues determine whether cancer cells use proteolytic or non-proteolytic invasion strategies in 3D tissue.
bioRxiv · Mar 16, 2022 · PreprintCancer Biology