L. Ran

UBAP2L drives scaffold assembly of nuclear pore complexes at the intact nuclear envelope

This study identifies UBAP2L's role in assembling functional nuclear pore complexes at the nuclear envelope by facilitating Y-complex formation and interactions with key nucleoporins.

KCNN4 links PIEZO-dependent mechanotransduction to NLRP3 inflammasome activation

The paper identifies KCNN4 as a mediator linking PIEZO mechanotransduction to NLRP3 inflammasome activation, showing its role in CAPS-related auto-inflammation.

Extracellular matrix guidance determines proteolytic and non-proteolytic cancer cell patterning

This study shows that matrix density and guidance cues determine whether cancer cells use proteolytic or non-proteolytic invasion strategies in 3D tissue.

Defective endosome-TGN retrograde transport promotes NLRP3 inflammasome activation

This study shows that defective endosome-TGN retrograde transport enhances NLRP3 inflammasome activation in macrophages, leading to increased inflammation and susceptibility to sepsis.