Cell intrinsic signaling in MEN1 mutant pancreatic neuroendocrine tumors unveils novel signaling pathways associated with de-differentiation
B. A. Rheinheimer, R. L. Heimark, A. D. Grant, L. Camacho, M. Padi, T. Jie
The paper identifies MEN1 and FGFR3 mutations in pancreatic neuroendocrine tumors and links them to de-differentiation and aggressiveness, suggesting FGFR3 as a therapeutic target.
bioRxiv · Sep 29, 2020 · PreprintCancer Biology