Time resolved quantitative phosphoproteomics reveals distinct patterns of SHP2 dependence in EGFR signaling
V. Vemulapalli, L. Chylek, A. Erickson, J. LaRochelle, K. Subramanian, M. Mohseni, M. LaMarche, M. G. Acker, P. K. Sorger, S. P. Gygi, S. C. Blacklow
The paper uses time-resolved phosphoproteomics to analyze SHP2's role in EGFR signaling, identifying distinct phosphotyrosine response patterns upon SHP099 treatment.
bioRxiv · Apr 12, 2019 · PreprintCell Biology